1999 Annual Report

July 1, 1998 - June 30, 1999

Faculty Appointments and Changes of Status
Regular, Research and Adjunct

July 1, 1998-June 30, 1999

Biostatistics
Thomas S. Lumley	Acting Assistant Professor	8/1/98
Anthony J. Rossini	Research Assistant Professor	8/1/98
Thomas S. Lumley	Assistant Professor (tenure track)	10/1/98
Alice Arnold	Lecturer Part-time	1/1/99
Polly Feigl	Professor Emeritus	4/1/99
Environmental Health
Timothy Takaro	Acting Assistant Professor	12/1/98
Thomas G. Martin	Adjunct Associate Professor	8/1/98
Epidemiology
Johanna Lampe	Research Assistant Professor	7/1/98
Barbara Bruemmer	Lecturer Part-time	7/16/98
Kathleen Malone	Research Assistant Professor	8/1/98
Karen Edwards	Assistant Professor	8/16/98
Russell Alexander	Professor Emeritus	7/1/98
Hjordis Foy	Professor Emeritus	8/1/98
Joanne Hoover	Research Associate Professor Emeritus	10/1/98
Health Services
Chaun-Fen Liu	Acting Assistant Professor	11/1/98
Matthew Maciejewski	Assistant Professor	2/1/99
Charles Maynard	Research Associate Professor	1/1/99
Michael Curtis	Research Associate	1/1/99-8/31/00
Jesse Malkin	Research Associate	1/1/99-8/31/00
Deborah Bowen	Associate Professor WOT	3/1/99
Edward Perrin	Professor Emeritus	1/1/98
Bobbie Berkowitz	Adjunct Professor	7/1/98
Wayne Katon	Adjunct Professor	9/1/98
Anna Mastroianni	Adjunct Assistant Professor	9/16/98
Jeffrey Jarvik	Adjunct Assistant Professor	3/1/99
Mari Kitahata	Adjunct Assistant Professor	4/1/99
Sanford Melzer	Adjunct Assistant Professor	4/1/99
Pathobiology
Nancy Haigwood	Associate Professor WOT	8/1/98
David Sherman	Assistant Professor (tenure track)	10/26/98
Sandra Schreyer	Research Associate	11/1/98

Clinical and Affiliate Appointments and Promotions

July 1, 1998-June 30, 1999

Biostatistics
Kathryn Davis Kennedy	Affiliate Professor	4/1/99
Charles Kooperberg	Affiliate Associate Professor	6/1/99
Environmental Health
Bradley Prezant	Affiliate Instructor	11/1/98
Stephen Bao	Affiliate Assistant Professor	5/1/99
Epidemiology
Debra L. Doyle	Affiliate Instructor	7/1/98
Thomas Becker	Affiliate Professor	12/1/98
Laurie Anderson	Affiliate Assistant Professor	3/1/99
Susan Nelson Steen	Affiliate Instructor	5/1/99
Health Services
Daniel Lessler	Clinical Assistant Professor	9/1/98
Marcia Legro	Clinical Assistant Professor	3/1/99
Robert D. Newman	Clinical Assistant Professor	3/1/99
Joseph Nichols	Clinical Assistant Professor	4/1/99
Frank James	Clinical Assistant Professor	4/1/99
Marin Andersen	Affiliate Assistant Professor	5/1/99
Pathobiology
Robert Hershberg	Affiliate Assistant Professor	4/1/99
Jun Wang Affiliate	Assistant Professor	6/1/99

Promotions and Tenure

Effective July 1, 1998

Biostatistics
Danyu Lin	Professor (T)
Environmental Health
Richard Fenske	Professor (with 50% tenure)
Matthew Keifer	Associate Professor WOT
Michael Morgan	Professor (with 50% tenure)
Noah Seixas	Associate Professor WOT
Michael Yost	Associate Professor WOT
Epidemiology
Cathy Critchlow	Associate Professor WOT
Peter Cummings	Associate Professor WOT
Robert L. Davis	Associate Professor WOT
Susan Heckbert	Associate Professor WOT
Bruce Psaty	Professor WOT, joint with Medicine
Mary Anne Rossing	Research Associate Professor
Health Services
Hendrika Meischke	Associate Professor WOT
Ann Downer	Senior Lecturer
Thomas Wickizer	Professor WOT
Pathobiology
Steven G. Reed	Research Professor

Visiting Faculty

July 1, 1998-June 30, 1999

Biostatistics
Per Zahl	Visiting Scholar	??-6/99
Environmental Health
Bruce Fowler	Visiting Professor	12/1/98
Epidemiology
Cheryl L. Rock	Visiting Associate Professor	3/29/99
Yechiel Friedlander	Visiting Professor	6/1/99
Health Services
Hiroshi Takahashi	Visiting Scientist	4/1/99
Pathobiology
Falk Jacques	Visiting Scientist	9/1/98

Faculty Honors, 1998-1999

Biostatistics

Norman Breslow

Statistician of the Year, American Statistical Association, Chicago Chapter, 1998

Scott Emerson

SPHCM Outstanding Teaching Award

Danyu Lin

Fellow, Institute of Mathematical Statistics, 1999
Mortimer Spiegelman Award, American Public Health Association, 1999

Margaret Pepe (Affiliate Associate Professor)

Genentech Distinguished Professor, 1999-2000

Nancy R. Temkin

1998 Richmond Cerebral Palsy Center Award

Elizabeth Thompson

Elected to American Academy of Arts and Sciences, 1998

Environmental Health

Jane Koenig

SPHCM Faculty/Staff Community Service Award

Curt Omiecinski

1998 Society of Toxicology Zeneca Award
1995-2000 Burroughs Wellcome Fund Toxicology Scholar Award

Mansour Samadpour

1998 Group Recognition Award from the US Food and Drug Administration for his team's work in solving the E. coli identification problem in the Odwalla apple juice case

Zhengui Xia

1999-2002 Burroughs Wellcome Fund New Investigator Award in Toxicology

Epidemiology

Maureen Henderson

Awarded the Order of the British Empire by Queen Elizabeth II, June 12, 1999

Walter Kukull

Selected participant, "Molecular Biology of Aging," Woods Hole, MA

Anne McTiernan

Elected, American College of Women's Health Physicians

Charles Mock

Peter C. Canizaro Prize for best paper presented by a new fellow, Annual Scientific Meeting of the American Association for Surgery of Trauma

Noel Weiss

UW Distinguished Graduate Mentor Award

Health Services

Steve Gloyd

Mid-Career Award, American Public Health Association, International Health Section

Susan Hedrick

Department of Veterans, Affairs Senior Research Career Scientist Award

Gayle Reiber

Department of Veterans, Affairs Research Career Scientist Award

Pathobiology

Sen-itiroh Hakomori

Citation for Distinguished Service from the Editorial Board, Journal of Biological Chemistry

Faculty Professional Service, 1998-1999

Biostatistics

William Barlow

Advisory Committee, American Statistical Association Joint Meeting, 1998-2000
Chair, Data Safety and Monitoring Committee, Early Surgery for Congenital Esotropia Trial (National Eye Institute-sponsored clinical trial), 1997-present

Jacqueline Benedetti

Statistical Editor, Journal of Infectious Disease
Co-Chair, GI Intergroup Common Data Elements Committee; Steering Committee, Intergroup Common Elements Project; Intergroup GI Correlative Sciences Review Committee

Norman Breslow

Associate Editor, Statistical Science
External Advisory Board, MD Anderson Hospital and Tumor Institute
Chair, IARC Research Training Fellowship Selection Committee
Guest Editor, Journal of the American Statistical Association, Special Section on Life and Medical Sciences

Paula Diehr

Associate Editor, Encyclopedia of Biostatistics
Editorial Board, Annual Review of Public Health, 1996-2000
Technical expert panel, "Performance Measurement in Medicare Fee for Service," Health Care Financing Administration, 1998
Consultant, "Multi-method Assessment of Medicaid Managed Care," University of New Mexico, 1998-2000

Scott Emerson

Statistical Editor, Journal of the National Cancer Institute
President-elect, International Biometric Society, Western North American Region (WNAR), 1998

Thomas Fleming

Chairman, New Zealand Health Research Council Data and Safety Monitoring Board
Member, Office of AIDS Research Therapeutic Research Working Group, 1997-present

Alfred Hallstrom

Board of Directors, Medic II Foundation
Member, Data Monitoring Board, MUSTT NIH-sponsored study

Patrick Heagerty

Member, NSF Review Service, Methodology, Measurement and Statistics Division of Social, Behavioral and Economic Research, 1998

James Hughes

Statistical Editor, Journal of Infectious Diseases, 1994-1998

Richard Kronmal

Member, Editorial Advisory Board, Statistical Methods in Medical Research; Associate Editor, 1997-present

Brian Leroux

Editorial Board, The Angle Orthodontist

Danyu Lin

Associate Editor, Biometrics
Associate Editor, Probability and Statistics Letters
Associate Editor, Biometrika

Barbara McKnight

International Biometric Society, Western North American Region (WNAR)
Representative to R.A. Fisher Lectureship Nominating Committee, 1998-2000

Ross Prentice

Associate Editor, Journal of the National Cancer Institute
Member, Food and Nutrition Board, Institute of Medicine, National Academy of Sciences, 1997-present
Member, Institute of Medicine Panel on Dietary Antioxidants, 1998-present

Anthony J. Rossini

Associate Editor, Journal of Statistical Software

Elizabeth Anne Sheppard

International Biometric Society, Western North American Region (WNAR) Student Paper Committee, 1998
US Environmental Protection Agency Review Panel of the Particulate Matter Air Quality Criteria Document, April 1999

Nancy Temkin

Data and Safety Monitoring Committee, Pfizer, 1998-present
NIH/NINDS Study Section, 1999-2002

Elizabeth Thompson

Associate Editor, Annals of Statistics
Council Member, International Statistical Institute, 1997-2001
President, International Biometric Society, Western North American Region (WNAR)

Mary Lou Thompson

Associate Editor, Biometrics
NRCSE Executive Committee, 1998-present

Ellen Wijsman

Review Panel, NIH NHLBI Mammalian Genotyping Service
Data and Safety Monitoring Board, NIH NHLBI Determinants of High Blood Pressure
Member, NIH NIA Genetic Epidemiology Advisory Group

Environmental Health

Drew Brodkin

President, Association of Occupational and Environmental Clinics; Chair, AEOC International Outreach Committee (1997-present)
Member, Planning Committee, NIOSH Workshop on Occupational Asthma: Current State of the Art

Tom Burbacher

Member, NIH Study Section on Musculoskeletal and Dental Sciences
Member, National Academy of Sciences Review Committee on Methylmercury
Member, Committee on Toxicological Effects of Mercury, National Research Council, National Academy of Sciences and Engineering
Member, Scientific Advisory Board, US Environmental Protection Agency, Mercury Review Subcommittee
Council member, Neurobehavioral Teratology Society
Member, Scientific Advisory Board, National Center for Toxicological Research (NCTR) Site Visit
Rapporteur, The Role of Environmental Neurotoxicants in Developmental Disabilities, the 20th Rochester Conference on Environmental Toxicity

Janice Camp

President-elect, Pacific Northwest Section, American Industrial Hygiene Association, 1998-1999

Harvey Checkoway

Member, Mine Health Research Advisory Council, NIOSH
Member, Site Visit Team for NIEHS Center, Wayne State University Institute for Chemical Toxicology
Member, Health Effects Institute Grant Review Committee, Diesel Epidemiology Project

Lucio Costa

Advisory editorial board member, Journal of Pharmacology and Experimental Therapeutics
Associate editor, NeuroToxicology, 1989-present
Editor, Current Protocols in Toxicology, 1997-present
Editorial board, Toxicology; Frontiers in Bioscience; Biomarkers
Member, Special Review Panel on Endocrine Disruptors, US Environmental Protection Agency
Member, Institute of Medicine/National Academy of Sciences Executive Committee on Health Effects Associated with Service in the Persian Gulf War

William Daniell

Member, Ergonomics Rulemaking Advisory Committee, Washington State Department of Labor and Industries
Affiliate Medical Consultant for Safety and Health, Washington State Department of Labor and Industries

David Eaton

Vice president-elect, Society of Toxicology, 1999-2000

Elaine Faustman

Board member and oversight committee, HESI, International Life Sciences Institute
Chair, Committee on Developmental Toxicology, National Academy of Sciences, National Research Council, 1997-present
Secretary-treasurer, Society of Toxicology, 1997-1999
Member, National Toxicology Program Advisory Committee on Alternative Toxicology Methods, NIEHS
External advisory board member, NIEHS Center in Developmental Toxicology and Molecular Biology, University of Wisconsin

Steven Guffey

Editorial board, American Industrial Hygiene Association Journal

David Kalman

Member, study section and site visitor, NIOSH Industrial Hygiene academic training grants, NIOSH Hazardous Substances training grants

Joel Kaufman

Member, ad hoc study section, NIOSH Review Panel for National Occupational Research Agenda Grants
Board officer, Northwest Association for Occupational and Environmental Medicine

John Kissel

Member, US Environmental Protection Agency Ad hoc Science Advisory Panel

Jane Koenig

Participant, EPA/Narsto Particulate Matter Workshop
Participant, Workshop on Health Effects of Climate Change, The Washington Advisory Group

Sally Liu

Co-Chair, International Society of Exposure Assessment, 1995-present

Daniel Luchtel

Program Director, Washington State, Pacific Northwest Microscopy Society of America, 1995-present

Michael Morgan

Chair, Biological Exposure Indices Committee, American Conference of Governmental Industrial Hygienists
Chair, site visit for NIOSH review of graduate programs in Occupational Health and Safety, University of Cincinnati
Cooperating Editorial Board, International Archives of Occupational and Environmental Health
Guest reviewer, Toxicological Sciences

Sharon Morris

Board of Scientific Counselors, National Institute for Occupational Safety and Health
Advisory Committee, APA Occupational Health Psychology
Steering Committee, NIOSH Training and Education Conference

Curt Omiecinski

Senior Councilor, Molecular Biology Specialty Section, Society of Toxicology
Member, NIH Clinical Sciences Special Emphasis Review Panel
Associate editor, Toxicological Sciences
Editorial board, Chemical-Biological Interactions

Noah Seixas

International editorial review board, Applied Occupational and Environmental Hygiene
Intramural Research Review Panel, National Cancer Institute, Occupational Studies Branch
Grant Review Panel, Health Effects Institute, "Assessing Personal Exposure to Selected Aldehydes"

Charles Treser

Planning committee, Washington State Environmental Health Association annual conference
Planning committee, Washington State Joint Conference on Public Health
SPHCM representative and coordinator for the 7th Annual National Conference on Distance Learning in Public Health

Gerald van Belle

Chair, Oversight Committee, National Morbidity and Mortality Air Pollution Study, Health Effects Institute, 1997-present
External advisor, Alzheimer Disease Research Center, Washington University and University of Southern California, 1998-present
Member, Peripheral and Central Nervous System Drugs Advisory Committee, Food and Drug Administration, 1999

Epidemiology

Melissa Austin

Special Emphasis Panel, NHLBI, "Future Directions in Training Heart, Lung, and Blood Disease Epidemiologists"
Member, Emerging Science Committee, CARDIA Study

Shirley Beresford

Editorial advisory board, Nutrition: The International Journal of Applied and Basic Nutritional Sciences

Cathy Critchlow

Consultant, FDA, Endocrinologic and Metabolic Advisory Committee

Adam Drewnowski

Co-executive editor, Appetite
Co-chair and organizer, Symposium on Diets, Supplements and Current Issues in Sports Nutrition, sponsored by the American Society for Clinical Nutrition and the American College of Sports Nutrition, in association with the UW Nutritional Sciences Program and the Clinical Nutrition Research Unit

Diana Farrow

External reviewer, Epidemiology Review Board, Department of Veterans’ Affairs Medical Research Service
Member, Pilot Projects Review Committee, FHCRC

James Gale

Member, Epidemiology and Biostatistics Panel to Evaluate the Predoctoral Fellowship in the Biological Sciences Program, Howard Hughes Medical Institute

Susan Heckbert

Associate Fellow, American Heart Association Council on Epidemiology and Prevention
Member, NIH Special Emphasis Panel, Cardiovascular Sciences Initial Review Group

Lisa Jackson

Member, NIAID Special Emphasis Panel, International Collaborations in Infectious Disease Research and Actions for Building Capacity in Support of ICIDR Program
Member, CDC Special Emphasis Panel, Prevention Research in Managed Care

Thomas Koepsell

Member, Planning Committee, Epidemiologic Study of Hepatitis C in US Veterans, Department of Veterans Affairs

Laura Koutsky

Member, American Social Health Association National HPV Scientific Advisory Committee

Walter Kukull

President, Neuroepidemiology Section, American Academy of Neurology
Chair, NINDS site visit team, Specialized Neuroscience Research Program
Member, external review committee, Mount Sinai School of Medicine Alzheimer's Disease Research Center

Kathleen Malone

FHCRC Institutional Review Board, 1997-present
FHCRC Specimen Processing Laboratory Oversight Committee
Study section reviewer, State of California Breast Cancer Program

Anne McTiernan

Member, American College of Sports Medicine

Charles Mock

Guest editor, Trauma Quarterly, issue on "International Approaches to Trauma Care"
Board of Directors, Association for the Advancement of Automotive Medicine; Chair, Task Group for Expanding International Relations
International Scientific Support Group, Fifth World Conference on Injury Control

Ruth Patterson

Editorial board: American Journal of Health Behavior; American Journal of Health Promotion; Public Health Nutrition

Bruce Psaty

Member, Morbidity and Mortality Review Committee, Mumand
Member, Steering Committee for the Collaborative Group in Hormonal Factors in Breast Cancer, Oxford University

Thomas Vaughan

Member, Epidemiology Study Section, Tobacco-related Disease Research Program, State of California

Anna Wald

Editorial board, Sexually Transmitted Infections
External consultant, CDC Genital Herpes Prevention Project
HSV Diagnosis Task Force
Board of Trustees, American Herpes Foundation

Emily White

Ad hoc Review Committee, National Cancer Institute of Canada

Michelle Williams

Editorial board, Epidemiology; Paediatric and Perinatal Epidemiology
Member, Board of Trustees, Seattle Biomedical Research Institute
Member, NIH Study Section, Epidemiology and Disease Control-1
Board of Scientific Counselors, NIEHS, Division of Intramural Research

Marsha Wolf

Peer grant reviewer, National Institute of Justice

Health Services

Michelle Bell

Member, Public Health Evaluation Center Technical Work Group, Seattle King County Department of Public Health, 1996-present

Doug Conrad

Editorial Board, Health Services Research
Health Services Research Study Section, AHCPR

Richard Deyo

National Research Council, Institute of Medicine Committee on Musculoskeletal Disorders and the Workplace
National Advisory Committee, Minority Medical Faculty Development, Robert Wood Johnson Foundation

William Dowling

Chair, National Steering Committee, Community Care Network Program, AHA/HRET-W.K. Kellogg Foundation

Steve Gloyd

External Advisory Committee, Masters in Health Policy, Boise State University
Editorial board consultant, International Journal of Health Services, International Health Section
Reviewer, Journal of American Public Health Association
Reviewer, European Journal of Public Health
Reviewer, American Journal of Tropical Medicine and Hygiene

Virginia Gonzales

Co-director, Fogarty Multidisciplinary International Research Training Program

Susan Hedrick

Editorial board, Health Services Research
Member, Health Services Research and Development Study Section, Department of Veterans Affairs
Member, Group Health Cooperative Research Committee

Colleen Morisset Huebner

Guest editor, NW Bulletin issue on early brain development
Participant, Washington Literacy Roundtable, to provide expertise on promoting language development through parent-child interaction
Member, Governor's Roundtable to promote research-practice-policy partnerships for quality infant and toddler childcare

Donna Johnson

Advisory Board, Childbirth Education Association of Seattle
Chair, Research and Awards Committee, Pediatric Nutrition Practice Group, American Diatetics Association
Steering Committee, Washington State Department of Health, Public Health Nutrition Data Committee
Steering Committee, Northwest Obesity Prevention Project

Aaron Katz

Peer reviewer, Health Affairs
Chair, Board of Directors, Center for the Advancement of Community-based Public Health

Ann Marie Kimball

Member, Integrated Assessment of Communicable Disease Surveillance in Korea, Seoul, Korea

James LoGerfo

Member, Institute of Medicine Technical Advisory Panel on Quality of Health Care in America
Member, Steering Committee for Clinical Outcome Assessment Program, Foundation for Health Care Quality

Carolyn Madden

Editorial Board, Medical Care Research and Review
External Advisory Committee, Masters in Health Policy, Boise State University

Charles Maynard

Faculty, VA 1999 Summer Epidemiology Program

Elaine Monsen

Editor, Journal of the American Dietetic Association
Consultant, Publications Management Committee, American Society of Clinical Nutrition

Gretchen Murphy

Editorial board, Journal of the American Health Information Management Association
Chair, ASTM subcommittee, Content and Structure of Electronic Health Records
Chair, Privacy Task Force of the CHITA program, in conjunction with the Foundation for Health Care Quality
Member, American Health Information Management Association Task Force on "Defining the Legal Patient"

Donald Patrick

Member, Institute of Medicine Committee on Measuring Health Status of Persian Gulf War Veterans
Member, Institute of Medicine Committee on Social Security Determination Research
Member, Institute of Medicine Committee on Measuring Health Status of Persian Gulf War Veterans
Member, Data and Safety Monitoring Committee, Age-Related Eye Disease Study, National Eye Institute
Member, Data and Safety Monitoring Committee, Collaborative Ocular Melanoma Study, National Eye Institute
Member, Data and Safety Monitoring Committee, Latino Eye Study
Member, Medical Outcomes Trust Scientific Advisory Committee
Editorial Board, Disability and Rehabilitation
Editorial Board, Quality of Life Research
Editorial Board, Research in Social Science and Disability

Gayle Reiber

Chair, Strategic Planning Committee, Washington State Department of Health Diabetes Control Program
Director, VA 1999 Summer Epidemiology Program
Executive board, Diabetes Quality Enhancement Research Initiative, Department of Veterans’ Affairs Activities

Mary Richardson

Program Organizing Committee, International Association of Scientific Studies in Mental Deficiency (IASSMD)
Past Chair, Association of University Programs in Health Administration
Editorial Board, Frontiers; Mental Retardation
Higher Education Committee, American College of Health Executives

Clarence Spigner

Peer reviewer, Journal of Adolescent Health
Grant reviewer, Public Health Traineeship Grants, Health Resources Services Administration
Member, African American Health Roundtable, Seattle-King County Health Department
Member, African American Health Coalition of Washington
Member, Steering Committee for the Comprehensive State-based Tobacco Use Prevention and Control Program, State of Washington Health Department
Chair, Special Committee for Minority Faculty Affairs, Faculty Senate, University of Washington

Beti Thompson

Reviewer, California Tobacco-related Disease Prevention Program, 1999
Contributing Author, Surgeon General’s Report on Women and Smoking

Thomas Wickizer

Contributing Editor, American Journal of Health Promotion
Member, State Advisory Committee for Alcohol and Substance Abuse Research, Olympia, Washington

Howard Zuckerman

Executive Committee, Board of Stewardship Trustees, Catholic Health Initiatives
Editorial board, Inquiry
Editorial board, Health Care Management Review
Editorial board, Advances in Health Care Management

Pathobiology

Marnix Bosch

Member, Regional Primate Center Research Advisory Committee
Member, Regional Primate Center Indonesia Committee

Lee Ann Campbell

Consultant, Virus Research Institute
Member, Bacteriology Mycology Study Section (NIAID)
Member, Small Business Innovation Research Grant Program
Member, US Delegation for NHLBI-sponsored US-Russian Joint Symposium in Basic Research in Cardiovascular and Pulmonary Diseases
Alternate Administrative Chair, Microbiological and Immunological Sciences Review Section

Jean Feagin

Author, SCOPE (Science Controversies On-Line: Partnerships in Education)

Sen-itiroh Hakomori

Member, Scientific Advisory Council, Cancer Research Institute
Editorial board, Cancer Research; Japanese Journal of Cancer Research; Glycoconjugate Journal; Glycobiology; Journal of Biological Chemistry

George Kenny

Editorial board, European Journal of Clinical Microbiology

Renee LeBoeuf

Member, NIH Ad hoc Study Section on Metabolism
Member, NIH Ad hoc P01 Review Committee
Member, Council on Deuell Conference on Lipid Metabolism

Sheila Lukehart

Member, NIAID Study Section on Microbiology and Infectious Disease Research Committee

Marilyn Parsons

Member, NIH Study Section on Tropical Medicine and Parasitology
Editorial board, Experimental Parasitology; Molecular and Biochemical Parasitology

Stephen Reed

Member, World Health Organization Vaccine Discovery Research Steering Committee
Advisor, World Health Organization Steering Committee on the Immunology of Mycobacteria
Associate editor, Experimental Parasitology; Journal of Immunology; Infection and Immunity

Marilyn Roberts

Founding board member, Antibiotic Resistance in Nonclinical Bacteria
Co-chair, Colloquium for the Academy of Microbiology, "Global Issues of Antibiotic Resistance: Ecology, Surveillance, and Use"
Outside thesis examiner, Postgraduate Section, University of Sydney
Chair, NIH Special Emphasis Panel; UW Special Committee on Women Faculty
Member, UW Faculty Senate Executive Committee and member, Faculty Council on Faculty Affairs

Michael Rosenfeld

Editorial board, Journal of Cardiovascular Pathobiology
Consultant, Cardiovascular Research Program, ICOS

David Sherman

Member, Study section on Bacteriology and Mycology
Member, Special Emphasis Panel, Microbial Physiology and Genetics Study Section

Ken Stuart

Grant reviewer, Human Frontiers of Science Program
External advisor, Fred Hutchinson Cancer Research Center Technology Transfer Committee

Ted White

Grant reviewer, New Zealand Health Research Council; Wellcome Trust; Austrian Science Fund
Member, Study Section AAR4 on AIDS Related Opportunistic Infections
Editorial board, Infection and Immunity

Faculty Community Service, 1998-1999

Biostatistics

Jacqueline Benedetti, Nancy Temkin and Ellen Wijsman

Quantitative Literacy Projects/Outreach: workshop for Seattle K-6 teachers; workshop for Everett Middle School teachers; workshop at Bremerton School District Faculty Development Conference

Barbara Richardson

Board of Directors, First Hill Child Learning Center, 1997-present

Environmental Health

Drew Brodkin

Presentations, "Respiratory Health of Seattle Firefighters," City of Seattle Fire Department
Consultant, Assessing Health Effects in Communities Near the Oakridge Facility

Lucio Costa

Member, Governor's Pesticide Advisory Panel
Member, Washington State Department of Health PIRT Panel

Elaine Faustman

Organizer, "The Risk Roundtable: Evaluating Risk from a Tribal Perspective," a CRESP-sponsored outreach event that convened tribes and regulators from across the nation to address tribal-specific risk issues
Organizer, The Hanford Openness Workshops, CRESP-sponsored outreach events that brought together federal, state, worker and other interests to improve public access to formerly secret and inaccessible DOE documents
Organizer, CRESP focus groups aimed at gaining a better understanding of the perception of the stakeholder risks associated with the transportation of nuclear waste to and from the Hanford DOE site

Richard Fenske

Alternate member, Washington State Pesticide Incident Tracking Panel

Gary Franklin

Scientific Advisory Board, National Multiple Sclerosis Society

Joel Kaufman

Member, Washington State Department of Health Advisory Committee on Childhood Blood Lead Screening Guidelines
Medical consultant, Washington State Surveillance Program on Occupational Lead Poisoning; Washington State Surveillance Program on Occupational Skin Disorders

Jane Koenig

Member, Advisory Council, Puget Sound Air Pollution Control Agency, 995-present

Sally Liu

Consultant to City of Medina, assisting in drafting a plan to assess the environmental impact of Highway 520

Charles Treser

Member, Brownfields Public Health Advisory Committee, organized by the Seattle-King County Department of Public Health as part of a project to encourage the redevelopment of closed or vacant industrial properties in the South Park and Ballard areas of Seattle
Coordinator, listserves and websites for the Washington Environmental Health Directors Association, Washington State Environmental Health Association, Public Health Training Network, Washington State Public Health Training Network, and a state vector control list

Epidemiology

Susan Astley

Member, Solutions for Chemically Dependent Women and Children

Christian Bynum

Presentations to 4th graders at Cherry Valley Elementary School about the importance of medical research and public health practice

Gary Goldbaum

Member, Decatur Elementary School Grants Committee for the support of educational programming

Thomas Koepsell

Member, External Advisory Group, Group Health Cooperative Center for Health Studies
Member, External Advisory Group, Cancer Prevention Research Program

Johanna Lampe

Advisory Board, Vegetarian Nutrition and Health Letter

Anne McTiernan

Participant, "Breast Cancer in Minorities," National Action Plan on Breast Cancer
Presentations to lay audiences' Breast Cancer Forum: Clinical Implications of Current Research, FHCRC; Women's Health Issues, The Healthy Living Expo

Bruce Psaty

Alumni Schools Committee, Princeton University
Member, Executive Council, American Heart Association Council on Epidemiology and Prevention

Noel Weiss

Advisory Board, KCTS Health Minutes project

Health Services

Allen Cheadle

Member, Community Board and Technical Advisory Group, Seattle Partners, a community-based organization with the Seattle-King County Health Department to implement and evaluate community health programs

William Dowling

Member, Advisory Council, Basic Health Plan, Washington State Health Care Authority
Member, Advisory Panel; Chair, Expanding Coverage and Access Task Force, Health Status and Health Systems Project, Seattle-King County Health Department

Virginia Gonzales

Board member, Northwest AIDS Foundation and Chair, International Committee of the NWAF International Committee
Member, Women and AIDS Task Force
Member, Scientific Advisory Group on Education (SAGE), Female Health Co., 1996-present

David Grembowski

Technical Advisory Group, Seattle Partners, a community-based organization with the Seattle-King County Health Department to implement and evaluate community health programs

Colleen Morisset Huebner

Created "Ready, Set, Read," a parent education pamphlet for Everett Deaconess Children's’ Services
Volunteer, Childhaven, a therapeutic child care center for maltreated infants and young children, providing training and expertise to staff and community volunteers in language development of at-risk children
Producing video to train parents of toddlers in methods of shared reading that promote early language development
Invited workshop participant, Region 2 DSHS (Yakima) on social influences on the emotional development of infants and toddlers
Invited speaker on early brain development, Northgate Group Health Pediatric Providers
Developer, chart on milestones and activities to promote early language development that was included in the "Zero to Three" website and in Parents magazine

Aaron Katz

Member, Board of Sponsors, Washington Physicians for Social Responsibility
Volunteer, Jewish Family Service "Big Pals" program

James LoGerfo

Member, Community Health Action Plan Advisory Committee, Seattle-King County Health Department
Member, Strategic Planning Committee, Northwest Kidney Center

Carolyn Madden

Trustee, The Little School

Elaine Monsen

Board, Puget Sound Blood Center

Clarence Spigner

Advisor, Seattle Partners, a community-based organization with the Seattle-King County Health Department to implement and evaluate community health programs
Advisor, Community Indicators for King County
Advisor, Washington Asian Pacific Island Families Against Substance Abuse

Beti Thompson

Tobacco Cessation Workgroup for Washington State Attorney General
Advisor, Washington Doctors Ought to Care (DOC)
Advisor, Tobacco Free Washington

Jack Thompson

Member, Cross-Cultural Health Care Program, Strengthening the Safety Net Advisory committee
Member, King County Indicators Project Steering Committee

Pathobiology

Lee Ann Campbell

Member, Chlamydia pneumoniae Advisory Board for Pasteur Merieux Connaught

Renee LeBoeuf

Scientific Advisory Board, American Heart Association, Washington Affiliate; Scientific Advisory Board, National American Heart Association
Co-director, American Heart Association, Affiliate Consortium, Scientific Review Board
Member, Juvenile Diabetes Association Scientific Review Board

Marilyn Parsons

Member, Pacific Science Council (scientific advisory board for the Pacific Science Center)

Stephen Reed

Member, American Heart Association Grant Review Study Section

Tim Rose

Member, Shoreline Community College Biotechnology Advisory Board
Ad hoc lecturer, Seattle Public Schools High School Science Program

Michael Rosenfeld

Member, American Heart Association Lesions Committee on the Council on Atherosclerosis; American Heart Association Program Committee on the Council on Atherosclerosis

Sandra Schreyer

Member, Science Education Partnership (through Fred Hutchinson Cancer Research Center)

Student Honors, 1998-1999

Biostatistics

Todd Alonzo

Best Oral Presentation, Student Paper Competition, International Biometric Society, Western North American Region (WNAR)

Tom Braun

Outstanding Student Presentation, International Biometric Society, Western North American Region (WNAR)
Biostatistics Senior Student Award
SPHCM Outstanding Student Award

Debashis Ghosh

Student scholarship to attend the 1999 Society of Clinical Trials meeting in Anaheim, CA

Chengcheng Hu

Donovan J. Thompson Award
Best Written Paper, 1999 Student Paper Competition, International Biometric Society, Western North American Region (WNAR)

Zoe Moodie

Postgraduate Scholarship B Fellowship from Natural Science and Engineering Council of Canada

Jennifer Clark Nelson

SPHCM Outstanding Student Award

Julie Stoner

Huckabay Teaching Fellowship, 1998-1999, used to design and teach a new undergraduate-level biostatistics course
SPHCM Outstanding Teaching Assistant Award

Environmental Health

Keriya Adem

SPHCM Outstanding Student Award

Stephanie Carter

3M Corporation Industrial Hygiene Scholarship

Ed Doran

US Environmental Protection Agency STAR Fellowship

Marie Foltz

Stockhausen Skine Care Division scholarship, selected by the Citizens’ Scholarship Foundation of America
SPHCM Outstanding Student Award

Doug Johns

Scholarship from the Pacific Northwest Section of the American Industrial Hygiene Association

Cecile Krejsa

SPHCM Outstanding Student Award

Janet Krober

Presidential Scholar Award

Ravi Sanga

Award for Best Student or Postdoctoral Research Presentation, 1998 Society of Toxicology Risk Assessment Specialty Section

Melissa Spenser

1999 Ed Pickett Memorial Scholarship, awarded by the Washington State Environmental Health Association in recognition of outstanding scholarship

Sue Swan

Stockhausen Skine Care Division scholarship, selected by the Citizens’ Scholarship Foundation of America

Kenton Wise

1998 Ed Pickett Memorial Scholarship, awarded by the Washington State Environmental Health Association in recognition of outstanding scholarship
1998 Mary Gates Endowment for Student Leadership Award

Epidemiology

Diana Buist

Huckabay Teaching Fellowship

Sascha Dublin

SPHCM Outstanding Student Award
1999 Prize for Student Paper, Society for Epidemiologic Research

Shelley Gray, PharmD

Mentored Clinical Scientist Development Fellowship, National Institute on Aging

Lucia Hindorff

Howard Hughes Fellowship

Aruna Kamineni

SPHCM Outstanding Teaching Assistant Award

Robert Kaplan

Howard Hughes Fellowship
SPHCM Outstanding Student Award

Victoria Moceri

National Institute on Aging Fellowship

Neli Ulrich

1999 prize for student paper, American College of Epidemiology

Patricia Yepassis-Zembrou

African-American Institute Fellowship

Health Services

Michelle Burley

Post Graduate Northwest Hospital Council Administrative Fellowship

Sophie Godley

SPHCM Outstanding Student Award

David Lee

NIDA national research fellowship to assist in a public health study of methamphetamine use

Mary McHugh

Sisters of Providence Post Graduate Administrative Fellowship

MaryAnn O'Hara-Hawn

First Place for poster presentation at the 3rd International Meeting of the Academy of Breastfeeding Medicine

Deborah Ostendorf Veres

David A. Winston Post Graduate Fellowship in Health Policy

Kathleen Porter

Abbot Fellowship awarded by Abbot Laboratories Symposium

Elizabeth Shea

1998 Arthur S. Farber Memorial Fund Award

Kristine Wong

Community Service Award, Annual Martin Luther King Tribute in Seattle
SPHCM Community Service Award
Semi-finalist, Do Something! Brick Awards Competition, a national award for activists under 30

Pathobiology

Zandrea Ambrose

1998-1999 Warren G. Magnuson Scholar
SPHCM Outstanding Student Award

Erin Harper

1998-1999 NIH Fellowship Recipient

Moffett Kable

1998-1999 UW Nominee, Distinguished Dissertation Award, Council of Graduate Schools

Rebecca LaFond

1998-1999 Honorable Mention, Graduate Research Fellowship, National Science Foundation

Vicki Luna

1998 Pasteur Merieux Connaught Award, North American recipient in Communicable Disease Epidemiology, 8th International Congress on Infectious Diseases
Travel award from the American Society for Microbiology

Cecilia Morgan

1998-2001 ARCS Award Recipient

Joell Solan

1996-1999 ARCS Award Recipient

Jia Song

NIH Fellowship Recipient

Eileen Sun

1997-2000 ARCS Award Recipient
1998-2001 NIH Fellowship Recipient, UW Center for AIDS and STD Research Training Grant

Student Community Service, 1998-1999

Biostatistics

Julie Stoner

Mentor, Making Connections Program, a UW program designed to ignite high school girls' interest in math and science

Brenda Kurland

Student representative and President-elect, Puget Sound Chapter of the American Statistical Association

Environmental Health

Sanders Chai

Member, Washington State Child Care Health and Safety Committee
Member, Master Home Environmentalist Program
Member, Head Start Advisory Committee

Alma Cardenas, Stephanie Carter, Dolo Diaz, Marie Foltz, Michael Garry, Noel Hudson, Nancy Judd, Hailing Lu

"Tox Ambassadors." These students have taught in over 26 classes and reached 600 students in grades K-12. The Health and Environmental Resources for Educators at the University of Washington (HERE@UW) program has developed a toxicology curriculum and resource kit prototype. The Tox-in-a-Box kit is designed for toxicologists and other environmental health professionals to use in outreach efforts to K-12 students and teachers.

Stephanie Carter, Marie Foltz, Golan Kedan, Phebe Mason, Aileen Mendoza, Stephanie Pingree, Sue Swan, Debbie Winterton

Participants, International Children’s Festival at Seattle Center. A 6-day festival that reached over 2000 school-age children and many teachers from around the region. Interactive exhibits included: "Breathe Easy," (asthma and how air pollution can trigger attacks); "The Water Challenge," (creating "wastewater" and trying to clean it up with screens and filters); "That Recyclin' Thing" (making recycled paper); and "Talkin' Trash" (teaching children to sort waste and teaching them the meaning of the words "Caution," "Warning," "Danger," and "Poison."

Epidemiology

[None, per Lee Carey]

Health Services

N. Susan Christ

Volunteer for Teen Feed, serving homeless youth
Lobbied in Olympia for Alzheimer's Association

Ted Eytan

Seattle Commissioner for Sexual Minorities, serving the Mayor and City Council

David Lee

Board member, NIH-sponsored National AIDS Clinical Trials Group

MaryAnn O'Hara-Hawn

Consultant, Healthy Mothers, Healthy Babies
Western Washington Steering Committee, Washington State Department of Health's Coalition on Breastfeeding

Rachel Shapiro

Health mentor for young adolescents in the Community Health and Advancement Program (CHAP)
Volunteer, Seattle Youth Garden Works program for high-risk teens and street youth

Elizabeth Shea

Volunteer board member, Shanti/Multifaith Works of Seattle

Kelly Stainback-Tracy

Volunteer, Children's Hospital
Volunteer, Fremont Public Association's Food Security for Children program

Pathobiology

Cynthia Cooper

High school student mentor, UW Women's Center
Student/teacher mentor for Science Educational Partnership (SEP), Fred Hutchinson Cancer Research Center

Whasun Chung

Mentor and career guidance counselor for junior and senior high school students, Korean Community Counseling Center
Speaker, Youth Leadership Conference, Seattle Pacific University

Ana Gervassi

Interpreter, Latin America grant reviews and proposals, Sustainable Sciences Institute, 1998-present
Interpreter, Red Cross Language Bank, 1993-present

New Grant Activity, 1998-1999

Biostatistics

Professor Richard Kronmal was awarded a 10-year contract entitled "Subclinical Cardiovascular Disease Study - Coordinating Center." The purpose of the project is to study the progression of subclinical cardiovascular disease to clinical cardiovascular disease in multiple ethnic groups.

Professor Thomas Fleming was successful in the competing renewal of his grant entitled "Statistical Issues in AIDS Research." The project addresses important issues in the statistical analysis of data from trials of interventions for treatment or prevention of HIV infection. This continues current work on mtional Institute for Occupational Safety and Health (NIOSH). Her study will assign measures of exposure to workers in a flock and flocked fabric manufacturing facility in which an investigation of an outbreak of interstitial lung disease is ongoing. Epidemiologic analyses of these populations will be used to search for associations between measures of exposure and the disease.

Funding was awarded to David Eaton by the National Institutes of Health to study the significance of genetic variation in estrogen metabolism. Estrogen has been shown to be an important risk factor for the development of both breast and endometrial cancer in women. The study hopes to determine if the known variants in human genes involved in catechol estrogen formation and elimination might be important determinants of individual susceptibility to estrogen related cancers, especially endometrial cancer. With a thorough understanding of how these genes modify estrogen metabolism we may one day be able to administer specific diets or even chemicals to make genetically susceptible people resistant to the DNA-damaging effects of endogenous estrogen.

Elaine Faustman, with deputy directors Thomas Burbacher and Richard Fenske, received joint funding from the US Environmental Protection Agency and the National Institute for Environmental Health Sciences to establish the University of Washington Center for Child Environmental Health Risk Research. The five-year study, announced at a White House ceremony, aims to improve the scientific understanding of the impacts of pesticide exposures on children's growth and development. The Center's basic research is linked with a community intervention project that aims to decrease pesticide exposures in children of farm workers in eastern Washington. Dr. Faustman also received funding from Carnegie Mellon University to merge the study to improve environmental health and safety regulations.

Terrance Kavanagh was funded by the US Environmental Protection Agency to study the effects of methylmercury exposure on a developing fetus, as the mother is exposed to low level exposures through common sources such as diet, dental amalgams and combustion of fossil fuels. The research, using animal models, will be conducted in association with the Institute of Neurotoxicology and Neurological Disorders (INND).

Matthew Keifer received funding via subcontract from the University of Minnesota's contract with the Centers for Disease Control (CDC) to study injuries among children and adolescents living and working on farms and ranches. The study will be conducted in the Yakima River Valley and the results will be used to direct future injury prevention efforts in pediatric populations living and working in agricultural environments.

Jane Koenig and deputy PI, David Kalman, received funding from the US Environmental Protection Agency to establish the Northwest Research Center for Particulate Air Pollution and health. The Center research will integrate the efforts of a multi-disciplinary team of scientists with expertise in environmental exposure assessment, toxicology, epidemiology, and biostatistics, whose combined efforts will address critical aspects of the health effects related to particulate matter (PM) air pollution.

Funding was awarded to Sally Liu by the US Environmental Protection Agency to determine the strength of the relationship of the outdoor PM exposures of high-risk subpopulations to the concentrations measured by a central monitoring station; to characterize the key factors influencing this relationship; and to link our data with other PM mortality-related studies in the Seattle area. This study will be conducted in the metropolitan Seattle area for 3 years. Dr. Liu also received funding from the Health Effects Institute to characterize personal exposures of 6 aldehydes in a large randomly selected population. The long-term objective of the study is to provide sufficient information on personal aldehyde exposures for accurate health risk assessment of aldehydes.

Zhengui Xia received funding from the National Institutes of Health to further study apoptosis, one of the major mechanisms for control of cell death. Abnormal apoptosis may cause or contribute to various neurodegenerative disorders including stroke, epilepsy, Parkinson's disease, Huntington's disease, and Alzheimer's disease. The overall objective of this study is to identify signal transduction pathways for apoptosis in neurons of the central nervous system, and to study their pathways for apoptosis in neurons of the central nervous system, and to study their pathways in response to several types of cellular stress.

Epidemiology

Melissa Austin received a one year Royalty Research Award to determine if small, dense LDL and insulin resistance are related and if the relationship is the same in lean and obese subjects. Shirley Beresford received a subcontract from the Fred Hutchinson Cancer Research Center on a grant to study the increase in fruit and vegetable intake by intervention at work sites without cafeterias. Peter Cummings received a 16 month-contract from the NIH for a planning study to determine the association of swimming lessons with drowning among children 12 to 59 months old.

Adam Drewnowski received a 1-year NIH award to study whether genetic food taste preferences exist that predispose a person to shun foods that can decrease cancer risks. Dr. Drewnowski also received a short-term grant from the State of Florida to test the hypothesis that genetic taste factors may limit compliance with cancer prevention diets which emphasize citrus fruits, vegetables and grains.

J. Thomas Grayston received awards from the NIH and Pfizer, Inc. to conduct a six-year clinical trial to determine the effectiveness of antibiotic therapy for the secondary prevention of complications of coronary artery disease. Laura Koutsky was awarded supplemental funds by Merck and Co. to expand the clinical trial of an HPV vaccine and to follow subjects for 4 years.

Steve Schwartz received a four-year award from NIH to study how common genetic susceptibility factors interact with common environmental factors to contribute to the coronary heart disease burden in the population. David Siscovick was awarded a five-year training grant by NIH to train students to conduct the highest quality cardiovascular research.

Noel Weiss received a one-year grant to assess the efficacy of PSA screening in reducing death due to prostate cancer. Dr. Weiss received partial salary support for two years to participate in the Veterans Administration ERIC study as an expert consultant.

Health Services

Bobbie Berkowitz (Adjunct Professor) was awarded a continuing grant from the Robert Wood Johnson Foundation under Turning Point: Collaborating for a New Century in Public Health, a joint program of the W.K. Kellogg Foundation and the Robert Wood Johnson Foundation. This project aims to strengthen state and local health departments in order to meet the challenges to population-based health care in the 21st century. A new grant for technical assistance was awarded for support of public health activities in fourteen states.

David Buchner received a four-year competing continuation Cooperative Agreement from the Centers for Disease Control to continue the Northwest Prevention Effectiveness Center.

Ann Downer, Director of the Center for Health Education and Research, received a five-year award from the U.S. Agency for International Development (USAID) to organize and coordinate a UW team for conducting work in the developing world. The purpose of the Synergy Project is to assist USAID missions in 45 countries with development of strategic plans for HIV/AIDS prevention, evaluation and monitoring of interventions, and broad dissemination of best practices on HIV prevention for developing countries. She also received support from the State of Washington Department of Health for continuation of an HIV intervention program.

David Grembowski received a new award from the Robert Wood Johnson Foundation to examine the influence of managed care on the quality of the patient-physician relationship among adult patients in primary care practices.

Donald Patrick received a new award from CDC through the Northwest Prevention Effectiveness Center for a study on Youth Quality of Life in Adolescents with ADHD. Dr. Patrick also received a new award from Columbia University, sponsored by NIH, for a two-year MPH research fellowship in collaboration with Rehabilitation Medicine. He is also the co-principal investigator on a Robert Wood Johnson foundation grant, Measuring Quality of Dying and Death.

Clarence Spigner received funding from the Centers for Disease Control through the Northwest Prevention Effectiveness Center for a study on Youth Responses to Tobacco Control Policies.

Pathobiology

Funding was awarded to Marnix Bosch to study Bacterial Toxins and Anti HIV-1 Immunity, Infection with HIV-1 worldwide occurs mostly through mucosal exposure, therefore first line defense against HIV-1 must include mechanisms that act at the mucosal surface. In addition it is desirable that cytotoxic T lymphocytes against the virus are induced in order to combat cells that become infected by virus that escaped from this first line of defense. An ideal HIV-1 vaccine would therefore induce both mucosal antibodies and CTL. Cholera Toxin (CT) and E. coli heat-labile enterotoxin (LT) have the capacity to do both. Chemical crosslinking of CT or LT to antigenic peptides of HIV-1 in theory would provide the following possibilities: oral, rectal or nasal administration of the immunogen, induction of cytotoxic T lymphocytes to the peptides, induction of mucosal and systemic antibodies to the peptides and to HIV-1 proteins, combination of multiple peptides from different HIV genes and from different variants in one immunogen. Dr. Bosch has established a successful procedure to crosslink peptides to CT and will use this procedure to determine 1) whether HIV-1 peptides crosslinked to the CT holotoxin confer enhanced immunogenicity when compared to CT mixed with either free peptides or HIV-1 gp120 proteins both systemically and at the mucosal surfaces when administered intranasally; 2) whether different routes of administration (including intranasally and intrarectally) of HIV-1 peptides crosslinked to or mixed with LT mutants induce anti HIV-1 antibodies and cytotoxic T lymphocytes; and 3) whether the system of crosslinking HIV-1 peptides to CT or LT mutants allows for simultaneous immunization with multiple epitopes by using antigenic peptides from both allelic variants of the same gene and of different HIV-1 genes.

Professor Lee Ann Campbell received funding for Development of Vaccine Strategies for Chlamydia pneumoniae. There is now considerable compelling evidence for the association of Chlamydia pneumoniae and atherosclerosis. Cumulative studies have shown evidence of the organism in coronary, carotid, aortic and femoral atheromas. The organism was detected in early lesions and developed plaques in both young and old persons in both genders. In no case was the organism detected in cardiovascular tissue that appeared to be "normal." If C. pneumoniae plays a role in atherogenesis, the impact on human health could be profound, as everyone is infected with C. pneumoniae in their life time and reinfection is common. Accordingly, it would suggest that intervention or preventive measures could alter the onset, severity, or progression of the disease. This project proposes to use mouse models of C. pneumoniae infection to study immune responses to infection and to test recombinant antigens that are recognized during human infection for their ability to induce resistance to infection or decrease severity of the disease process.

Dr. Campbell also was awarded funding for the grant "Study of the Effects of Azithromycin on Chronic Chlamydia pneumoniae Infection of the Aorta in Mice." Although an etiology has not been firmly established, studies in animal models and results from pilot human intervention studies support a role of C. pneumoniae infection in atherosclerosis. The purpose of this proposal is to study the effect of treatment of chronic C. pneumoniae infection in lungs and the aorta of mouse models of C. pneumoniae infection and atherosclerosis using the antibiotic azithromycin. Specifically, we will determine whether 1) different treatment regimens eradicate the organism from the lung, normal aorta, and aortas with atheromas and 2) treatment prevents or decreases negative outcome.

Dr. Campbell also received funding to study Chlamydia pneumonia antigens of biological significance. C. pneumoniae is a human respiratory pathogen. Recently, the clinical spectrum of C. pneumoniae has been extended to an association with atherosclerosis. If the organism is shown to play a role in atherogenesis, there will be an urgent need to identify vaccine candidates and to develop rapid diagnostic methods. The purpose of this grant is to perform molecular, functional, and antigenic analyses of C. pneumoniae antigens that are recognized during human infection, elicit a protective immune response, and/or are involved in C. pneumoniae pathogenesis.

Affiliate Associate Professor Gael Kurath received funding for her grant "DNA Vaccines for Salmonid Fishes." DNA vaccines have been shown in mammalian model systems to have great potential as novel therapeutic agents which overcome some of the drawbacks of traditional vaccines. Preliminary work has shown that a DNA vaccine against infectious hematopoietic necrosis (IHN) virus elicits an immune response in trout and protects them from subsequent infection with the virus. The proposal continues development of this vaccine by testing minimal dose, use in larger fish, different vaccine expression, the persistence of expression, any potential tissue damage, and the nature of the immune response of the fish to the vaccine. These studies comprise a model system for understanding DNA vaccines in fish, against an extremely important salmon pathogen.

Professor Renee LeBoeuf is the PI of Development of Atherosclerosis in Diabetic Mice. The long-term goal of the study is to identify molecular mechanisms for the onset of accelerated atherosclerosis in diabetes mellitus. This will be accomplished by studying animal models susceptible to both diabetes and atherosclerosis. These models will be used to identify genetic and environmental factors influencing atherosclerosis due to the diabetic state, and to explore possible steps toward treatment or prevention of atherosclerotic disease in diabetics. Most of the diabetic models can be studied in the presence and absence of diabetes, allowing direct assessment of the diabetic state of lesion etiology. This animal model approach will clarify pathophysiological mechanisms leading to atherosclerosis in diabetes. Future studies will be directed toward identifying treatments useful for retarding and reversing dyslipoproteinemia and atherosclerosis in diabetics.

Dr. LeBoeuf also received funding for a study entitled "Modeling Alzheimer's Disease: B-amyloid and Apo E." Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive loss of memory and cognitive functions. The long-term goal of this research is to elucidate the role of B-amyloid protein (AB) and apolipoprotein (apo) E in the pathogenesis of AD. A possible role for AB as either marker for AD onset and progression or as a causative factor is supported by its marked accumulation in neuritic plaques and cerebrovascular sites. Genetic, epidemiological, and biochemical evidence is mounting that apoE exerts an isoform specific-effect on the rate or extent of development of AD. The development of animal models expressing various forms of apoE in the presence of marked amyloid expression may provide excellent tools in which to study the progression, prevention and treatment of AD.

Professor Michael Rosenfeld was awarded funding to study Homocysteine, Inflammation, and Atherogenesis. Homocysteinemia is now a well-recognized independent positive risk factor for cardiovascular and peripheral vascular diseases. However, the exact mechanism(s) by which elevations in the levels of this amino acid in the plasma contribute to the disease process at the level of the artery wall are not known. Thus, the long-term goal is to identify the molecular and cellular mechanisms by which homocysteinemia contributes to the accelerated formation of atherosclerotic vascular disease and to explore steps towards eventual prevention and treatment. We hypothesize that chronic homocysteinemia accelerates atherosclerosis by stimulating and/or killing inflammatory cells within developing lesions and that this stimulation and/or cell death is due to the depletion of the primary intracellular antioxidant glutathione and the reduction in the availability of NADH/NADPH. In this proposal we use cell culture and animal models to test our hypotheses. Our specific aims are 1) to determine how elevated homocysteine and lipid accumulation alter glutathione and NADH/NADPH metabolism in macrophages in vitro and whether these alterations induce cellular activation and/or death and 2) to determine the effects of increased plasma homocysteine on the development of atherosclerosis in mice.

1998-1999 Grants Awarded

During the period July 1, 1998 through June 30, 1999, 70 new grants were awarded, for a multi-year total of $50,320,497. Of this, $10,969,443 is available during the current year. Added to 224 continuing grants which total $26,382,465, the total for 1998-1999 is $37,351,908. The direct expenditures on grants and contracts (excluding indirect costs awarded) comes to $31,144,844.

		95-96	96-97	97-98	98-99
Resources
Sources of SPHCM Funds, 1995-1999
State Funds
	General Funds	3.23	3.56	3.87	3.98
	Labor & Industry	4.78	4.30	4.79	4.98
	RCR, UIF, Evening Degree, etc.	3.21	2.97	3.72	3.76
	Subtotal	11.22	10.83	12.38	12.69
Grants & Contracts		25.64	27.17	27.38	31.15
Grand Total		36.86	38.00	39.76	43.84

Gifts, 1998-1999
Total number of gifts:	648
Total net amount:	$163,752

Gift Purpose	Net Amount	% of Total Net Amount
Student Aid/Awards	$42,295	26%
Academic Support	$55,085	34%
Research	$66,372	40%

Staff Length of Service

Staff in the SPHCM with 15 or more years of UW service

Biostatistics

Velta Benson, LaTanya Boyd-McKinney, Michael Dermond, Nora Dermond, David Fetrow, Barbara Jensen, Lillian Kato, Robert Ledingham, Mary Morris, Margit Scholz

Environmental Health

Tom Aquino, John Boykin, Jean Garber, Nick Heyer, Neil Horike, Bud Van Ryn

Epidemiology

Lee Carey, Ophelia Ealy

Health Services

Kitty Andert, Lynn Gose, Laura Larsson, Lucena Lanot, Steve Leigh, Ginger McMahan

Pathobiology

Frank Cartwright, Chris Hass, Amy Lee, Elsie Lee, Ingrid Noe

Dean's Office

Ken Anderson, Helen MacQueen

Staff in the SPHCM with 10-14 years of UW service

Biostatistics

Diane Ames, Kevin Cain, Lorraine Cain, Annette Fitzpatrick, Jonna Kincaid, Bonnie Lind, Eric Maddox, Cynthia Marks, Elaine Riot, Ellie Schweihs

Environmental Health

Pat Janssen, Rosemary Schaffer, Azure Skye

Epidemiology

Darlene Boday, Kate O'Brien

Health Services

Gail Greenwood, Rita Keating, Bob Shimabukuro

Pathobiology

David Grayston